Clindamycin phosphate topical solution clindamycin. Webmd provides common contraindications for clindamycin hcl oral. Choose from 414 different sets of clindamycin flashcards on quizlet. Dalacin c clindamycin hydrochloride is indicated in the treatment of serious. Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg or 300 mg of clindamycin. This class was first characterized in the 1960s and is now used for treatment of a broad spectrum of infections rezanka et al. As with lincomycin, antibacterial activity results from inhibition of protein synthesis. Dec 20, 2018 clindamycin is a lincosamide antibiotic with a primarily bacteriostatic action against grampositive aerobes and a wide range of anaerobic bacteria. Dtest for detection of antimicrobial susceptibility in methicillin resistant staphylococcus aureus mrsa flora grace m ph. Administrative details substance invented name clindamycin authorisation procedure noncentralised.
The most clinically relevant lincosamide, clindamycin, is frequently used to treat. What is the exact mechanism of action of clindamycin. Clindamycin drug interaction with warfarin leading to international normalised ratio inr increased this is a recommendation from the pharmacovigilance risk assessment committee prac of the european medicines agency ema. Clindamycin binds 50s ribosome, blocks peptide elongation. The same mode of action was described for azithromycin two years later. Learn clindamycin with free interactive flashcards. Clindamycin has the potential to cause adverse effects on the breastfed infants gastrointestinal flora. Oct 17, 2016 clindamycin phosphate topical solution, usp 1% contains clindamycin phosphate, usp, at a concentration equivalent to 10 mg clindamycin per milliliter. Inducible clindamycin resistance in staphylococcus aureus. Clindamycin may potentiate the opsonization and phagocytosis of bacteria even at subinhibitory concentrations. I was prescribed the antibiotic clindamycin last april by my dentist because i had a gum irritation. Inhibits peptidyl transferase by interfering with binding of amino acidacyltrna complex resistance methylation of 23s ribosomal rna subunit.
See azithromycin and clarithromycin, section on mechanism of action and chemical structure. Apr 08, 2014 i was prescribed the antibiotic clindamycin last april by my dentist because i had a gum irritation. Randomized clinical trials level 1 evidence support the use of clindamycin in a. Basic mechanisms of antibiotic action and resistance. Clindamycin has been reported to appear in breast milk in range of 0. Ask your health care provider about possible side effects from clindamycin. Examples of the infections include serious respiratory tract infections, skin and soft tissue infections, infections of the female. Cleocin phosphate injection clindamycin dose, indications. Clindamycin is an alternative choice for mild to moderate mrsa infections especially in. Feb 12, 2016 these findings contributed to the antiplasmodial action of clindamycin after 3 days of administration. Clindamycin should be used with caution in infants up to 1 month of age.
Clindamycin is an inhibitor of protein synthesis in the bacterial cell. Cleocin hcl capsules clindamycin clinical pharmacology. Clindamycin is a semisynthetic antibiotic produced by a 7schlorosubstitution of the 7rhydroxyl group of the parent compound lincomycin. The resistance to macrolide can be mediated by msr a gene coding for efflux mechanism or via erm gene. Chemical structure, biosynthesis, mechanism of action, resistance, and applications natural lincosamides are produced by. But clindamycin hydrochloride suffers from a major drawback of having very low topical bioavailability of only 45%. Tetracyclin spectinomycin streptomycin gentamycin tobramycin kanamycin amikacin dhf thf paba folic acid metabolism. So that a site is unable to bind with the next aminoacyl t rna complex. Macrolides and associated antibiotics based on similar. Clindamycin is also available as a topical solution, gel, or lotion and as a vaginal cream. Media in category clindamycin the following 15 files are in this category, out of 15 total. Cleocin phosphate in the addvantage vial is intended for intravenous use only after further dilution with appropriate volume of addvantage diluent base solution see directions for use cleocin phosphate iv solution in the galaxy plastic container for intravenous use is composed of clindamycin phosphate equivalent to 300, 600 and 900 mg of clindamycin.
Intravenous metronidazole or clindamycin with tobramycin for therapy of pelvic infections. Clindamycin phosphate is a water soluble ester of the semisynthetic antibiotic produced by a 7s chlorosubstitution of the 7rhydroxyl group of the parent antibiotic lincomycin. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. This makes an exceptionally compelling story, as it explains most of the observed immunomodulatory effects of these drugs and, to a great extent.
Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per ml in an isopropyl alcohol and water solution, very low levels of clindamycin are present in the serum 03 ngml and less than 0. Doxycycline has bacteriostatic activity against a broad range of grampositive and gramnegative bacteria. This page was last edited on 10 december 2014, at 17. Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. There are several reports of its local anaesthetic i and neuromuscular blocking ac. Q8 compare and contrast the mechanism of action, spectrum. Clindamycin, a lincosamide antibiotic, is most commonly for the treatment of acne as compared to other available treatment because it directly kills the bacteria which is associated with acne. The mechanism of action of clindamycin in combination with. Clindamycin binds the 50s subunit, comprising ribosomal 23s, 5s and ribosomal proteins l4 and l22. Binds to the 50s ribosomal subunit of rrna and inhibits the initiation of peptide chain synthesis.
Cleocin, clindesse clindamycin dosing, indications. The resistance to antimicrobial agents among staphylococci is an increasing problem. It can also be used to treat acne, and some cases of methicillinresistant staphylococcus aureus mrsa. Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per ml in an isopropyl alcohol and water solution, very low levels of clindamycin are present in the serum 03. Clindamycin phosphate topical solution, usp 1% contains clindamycin phosphate, usp, at a concentration equivalent to 10 mg clindamycin per milliliter. Following parenteral administration, biologically inactive clindamycin phosphate is rapidly hydrolyzed in plasma to active. I was prescribed the antibiotic clindamycin last april by my. Quinine duration is region specific, consult cdc for current recommendations cdc, 2009 malaria, uncomplicated treatment unlabeled use. Clindamycin about clindamycin macrolide, lincosamide antibiotic. Clindamycin drug interaction with warfarin leading to inr.
Q8 compare and contrast the mechanism of action, spectrum of. The binding site for clindamycin is on the 50s subunit of the bacterial ribosome which is identical with that for erythromycin. Dtest for detection of antimicrobial susceptibility in. Clindamycin phosphate topical solution clindamycin phosphate. Use with ceftriaxone or cefoxitinprobenecid if no proceeding iv treatment. Reproduction studies performed in rats and mice using oral doses of clindamycin up to 600 mgkgday 2. This has led to renewed interest in the usage of macrolidelincosamidestreptogramin b mls b antibiotics to treat staphylococcus aureus s.
I was prescribed the antibiotic clindamycin last april by. Files are available under licenses specified on their description page. Monitor the breastfed infant for possible adverse effects on the gastrointestinal flora, such as diarrhea, candidiasis thrush, diaper rash or rarely, blood in the stool indicating possible antibioticassociated colitis. Trimethoprim sulfoamids paba paminobenzocis acid, dhfdihydrofolate, thftetrahydrofolate essential for growth of bacteria genetic.
In recent times, clindamycin has become an excellent drug for some staphylococcal infections, particularly skin and soft tissue infections and as an alternative in penicillinallergic patients. Its similarity to the mechanism of action of macrolides and chloramphenicol means they should not be given simultaneously, as this causes antagonism. Apr 07, 2020 reproduction studies performed in rats and mice using oral doses of clindamycin up to 600 mgkgday 2. Cleocin t clindamycin warnings and precautions pfizer. All structured data from the file and property namespaces is available under the creative commons cc0 license. Clindamycin binds to the 23s rna of the 50s ribosomal subunit of the bacteria, which inhibits protein synthesis. The frequency of antibiotic resistance and positive d. Clindamycin, like erythromycin, suppresses protein synthesis by interfering with the development of initiation complexes and with aminoacyl translocation reactions. Clindamycin hydrochloride drug information, professional. Dec 19, 2018 clindamycin may affect the way other medicines or products work, and other medicines or products may affect how clindamycin works. Find out what health conditions may be a health risk when taken with clindamycin hcl oral.
The lincosamide class of antibacterials originates from a natural product, lincomycin, and includes semisynthetic derivatives, clindamycin and pirlimycin. Clindamycin is an antibiotic used for the treatment of a number of bacterial infections, including. Microsoft word q8 compare and contrast the mechanism of action, spectrum of activity and adverse effects of benzyl penicillin, metronidazole and clindamycin march 20. Clindamycin inhibits bacterial protein synthesis by binding to the 23s rna of the 50s subunit of the ribosome. It is mostly active against grampositive organisms, but also finds use against. Clindamycin should not be used as an antimalarial by itself, although it appears to be very effective as such, because of its slow action. Clindamycin is a lincosamide antibiotic used to treat certain kinds of bacterial infections. The mechanism of action of clindamycin in treating acne vulgaris is unknown. Clindamycin 150mgml solution for injection or infusion.
Antibiotic drugs, information, description on clindamycin. The site of binding appears to be in the 5os subunit of the ribosome. D test method for detection of inducible clindamycin in. Doxycycline inhibits bacterial protein synthesis by binding to the 30s ribosomal subunit. Research scholar department of zoology, madras christian college autonomous, tambaram, tamil nadu, india, abstract. Structure and mechanism of the lincosamide antibiotic.
Also, clindamycin has good oral bioavailability making it a good option for outpatient therapy and changeover after intravenous antibiotics. The usual agents adrenaline, corticosteroids, antihistamines, colloid infusion should be available for. It will not work for colds, flu, or other viral infections. Food and drug administration fda for the treatment of serious infections caused by certain types of bacteria. I have been taking antibiotics for the c difff for 11 months. The solution and the lotion are used on the skin to treat acne.
Clindamycin is a lincosamide antibiotic with a primarily bacteriostatic action against grampositive aerobes and a wide range of anaerobic bacteria. Mechanism of action of clindamycin it binds to the 50s sub unit of bacterial ribosome and inhibits translocation. Clindamycin is an antibacterial prescription medicine approved by the u. Disrupt bacterial cell envelope block production of new proteins inhibit dna replication. Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg, or 300 mg of clindamycin. Doxycycline fda prescribing information, side effects. Patients receiving clindamycin and develop loose stoolsdiarrhea should have stool culture sent for c.
Mechanism of action of clindamycin student doctor network. I now see that the clindamycin is on the black list of medications. Cleocin phosphate in the addvantage vial is intended for intravenous use only after further dilution with appropriate volume of addvantage diluent base solution see directions for use cleocin phosphate iv solution in the galaxy plastic container for intravenous use is composed of clindamycin phosphate equivalent to 300, 600 and 900 mg of. Ask your health care provider if there are interactions between clindamycin and the other medicines you take. Clindamycin drug interaction with warfarin leading to. The concentration of clindamycin in diluent for infusion should not exceed 18 mg per ml. Clindamycin and macrolides both inhibit the translocation step same. These findings contributed to the antiplasmodial action of clindamycin after 3 days of administration. Mechanisms of action antibiotics act by disrupting various molecular targets within bacteria and cell surface, preventing growth or initiating killing. How to use clindamycin phosphate vial this medication is given by injection into a vein or muscle as directed by your doctor, usually 2 to 4 times a day. Clindamycin and the related drug lincomycin are often discussed along with the macrolides but are not chemically related. Clindamycinresistant streptococcus pneumoniae to the editor.
Clindamycin topical lotion 1pct drug medication dosage information. Clindamycin topical lotion 1pct drug medication dosage. Lincosamides such as clindamycin bind to the 50s subunit of the bacterial ribosome similarly to macrolides such as erythromycin and inhibit the early stages of protein synthesis. In combination with quinine, it can be used for malaria. Cleocin hclclindamycin hydrochloridecapsules, usp page 1 of. Clindamycin lincomycin streptogramins oligosaccharides protein syntesis 30s inhibitorer. Clindamycin is a wellknown cause of pseudomembranous colitis, possibly due to overgrowth of clostridia difficile, and 10% to 20% of strains of clostridia perfringens can be resistant to clindamycin. Close monitoring in patients concomitantly receiving neuromuscular blocking agents. Cross resistance with other tetracyclines is common. The preponderance of published data strongly suggest that a primary immunomodulatory mechanism of action is through the macrolide effects on mapk activation, in particular, via the erk12 pathway.
Clindamycin contains an antibiotic called clindamycin phosphate and comes as either a solution or lotion. Clindamycin is an antibiotic used for the treatment of a number of bacterial infections, including bone or joint infections, pelvic inflammatory disease, strep throat, pneumonia, middle ear infections, and endocarditis. A reduction in the dose of these agents may be necessary. Cellulitis possibly due to mrsa unlabled use 300450mg po q8hr x 510 days. Clindamycin usual diluents d5w, ns standard dilution amount of drug infusion volume infusion rate dilution and infusion rates clindamycin phosphate must be diluted prior to iv administration. Each capsule contains 150 mg of clindamycin hydrochloride as active ingredient.